Finally steroid, we apply stretching to the chain to approximate flow induced crystallisation and investigate the effect of different degrees of stretch on the nucleation barrier.We verify the quality of our simulation with careful monitoring of several criteria, including the acceptance ratios of configuration swaps between simulations with adjacent temperatures steroid, evolution of the energy traces as a result of configuration swaps between tempering levels steroid steroid, and ensuring effective de correlation of configurations through reptation moves. Our simulations provide strong reproducible results for the base, the peak and beyond the peak of the barrier for the quiescent and stretched single chain. We observe a remarkably strong effect of modest stretching on the nucleation barrier for a single chain, which can potentially lead to dramatic effects on the nucleation rate.
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steroids drugs The risk of reaching Expanded Disability Status Scale score milestones of 4 and 6 in ever smokers compared to never smokers was 1.34 (95% confidence interval: 1.12 “1.60) and 1.25 (95% confidence interval: 1.02 “1.51) respectively. Current smokers showed 1.64 (95% confidence interval: 1.33 “2.02) and 1.49 (95% confidence interval: 1.18 “1.86) times higher risk of reaching Expanded Disability Status Scale scores 4 and 6 compared with non smokers. Ex smokers who stopped smoking either before or after the onset of the disease had a significantly lower risk of reaching Expanded Disability Status Scale scores 4 (hazard ratio: 0.65, confidence interval: 0.50 “0.83) and 6 (hazard ratio: 0.69, confidence interval: 0.53 “0.90) than current smokers, and there was no significant difference between ex smokers and non smokers in terms of time to Expanded Disability Status Scale scores 4 or 6. steroids drugs
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